منابع مشابه
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2
Forebrain neurons have weak intrinsic antioxidant defences compared with astrocytes, but the molecular basis and purpose of this is poorly understood. We show that early in mouse cortical neuronal development in vitro and in vivo, expression of the master-regulator of antioxidant genes, transcription factor NF-E2-related-factor-2 (Nrf2), is repressed by epigenetic inactivation of its promoter. ...
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ژورنال
عنوان ژورنال: New Scientist
سال: 2020
ISSN: 0262-4079
DOI: 10.1016/s0262-4079(20)30633-3